Functional Analysis of Mouse G6pc1 Mutations Using a Novel In Situ Assay for Glucose-6-Phosphatase Activity and the Effect of Mutations in Conserved Human G6PC1/G6PC2 Amino Acids on G6PC2 Protein Expression

Elevated fasting blood glucose (FBG) has been associated with increased risk for development of type 2 diabetes. Single nucleotide polymorphisms (SNPs) in G6PC2 are the most important common determinants of variations in FBG in humans. Studies using G6pc2 knockout mice suggest that G6pc2 regulates t...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Boortz, Kayla A., Syring, Kristen E., Pound, Lynley D., Wang, Yingda, Oeser, James K., O’Brien, Richard M.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5017610/
https://ncbi.nlm.nih.gov/pubmed/27611587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162439
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