Targeting c-Met in melanoma: Mechanism of resistance and efficacy of novel combinatorial inhibitor therapy

Numerous tyrosine kinase inhibitors (TKIs) targeting c-Met are currently in clinical trials for several cancers. Their efficacy is limited due to the development of resistance. The present study aims to elucidate this mechanism of c-Met TKI resistance by investigating key mTOR and Wnt signaling prot...

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Detalhes bibliográficos
Main Authors: Etnyre, Deven, Stone, Amanda L, Fong, Jason T, Jacobs, Ryan J, Uppada, Srijayaprakash B, Botting, Gregory M, Rajanna, Supriya, Moravec, David N, Shambannagari, Manohar R, Crees, Zachary, Girard, Jennifer, Bertram, Ceyda, Puri, Neelu
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128856/
https://ncbi.nlm.nih.gov/pubmed/24914950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.29451
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