Targeting c-Met in melanoma: Mechanism of resistance and efficacy of novel combinatorial inhibitor therapy

Numerous tyrosine kinase inhibitors (TKIs) targeting c-Met are currently in clinical trials for several cancers. Their efficacy is limited due to the development of resistance. The present study aims to elucidate this mechanism of c-Met TKI resistance by investigating key mTOR and Wnt signaling prot...

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Détails bibliographiques
Auteurs principaux: Etnyre, Deven, Stone, Amanda L, Fong, Jason T, Jacobs, Ryan J, Uppada, Srijayaprakash B, Botting, Gregory M, Rajanna, Supriya, Moravec, David N, Shambannagari, Manohar R, Crees, Zachary, Girard, Jennifer, Bertram, Ceyda, Puri, Neelu
Format: Artigo
Langue:Inglês
Publié: Landes Bioscience 2014
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128856/
https://ncbi.nlm.nih.gov/pubmed/24914950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.29451
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