hnRNP C1/C2 and Pur-beta proteins mediate induction of senescence by oligonucleotides homologous to the telomere overhang

BACKGROUND: Experimental disruption of the telomere overhang induces a potent DNA damage response and is the target of newly emerging cancer therapeutics. Introduction of T-oligo, an eleven-base oligonucleotide homologous to the 3′-telomeric overhang, mimics telomere disruption and induces DNA damag...

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Detalhes bibliográficos
Main Authors: Mulnix, Richard E, Pitman, Ryan T, Retzer, Allison, Bertram, Ceyda, Arasi, Kavin, Crees, Zachary, Girard, Jennifer, Uppada, Srijayaprakash B, Stone, Amanda L, Puri, Neelu
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3872271/
https://ncbi.nlm.nih.gov/pubmed/24379680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S54575
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