TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I

The US11 gene product of human cytomegalovirus promotes viral immune evasion by hijacking the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. US11 initiates dislocation of newly translocated MHC I from the ER to the cytosol for proteasome-mediated degradation. Despite the critical...

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Bibliografiska uppgifter
Huvudupphovsmän: van den Boomen, Dick J. H., Timms, Richard T., Grice, Guinevere L., Stagg, Helen R., Skødt, Karsten, Dougan, Gordon, Nathan, James A., Lehner, Paul J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2014
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128144/
https://ncbi.nlm.nih.gov/pubmed/25030448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409099111
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