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Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I
The human cytomegalovirus (HCMV) US2 and US11 gene products hijack mammalian ER-associated degradation (ERAD) to induce rapid degradation of major histocompatibility class I (MHC-I) molecules. The rate-limiting step in this pathway is thought to be the polyubiquitination of MHC-I by distinct host ER...
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| Publicado no: | Mol Immunol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Pergamon Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4678111/ https://ncbi.nlm.nih.gov/pubmed/26210183 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2015.07.005 |
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