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MHC class I molecules are preferentially ubiquitinated on endoplasmic reticulum luminal residues during HRD1 ubiquitin E3 ligase-mediated dislocation

Misfolded MHC class I heavy chains (MHC I HCs) are targeted for endoplasmic reticulum (ER)-associated degradation (ERAD) by the ubiquitin E3 ligase HRD1, and E2 ubiquitin conjugating enzyme UBE2J1, and represent one of the few known endogenous ERAD substrates. The mechanism by which misfolded protei...

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Bibliografiske detaljer
Main Authors: Burr, Marian L., van den Boomen, Dick J. H., Bye, Helen, Antrobus, Robin, Wiertz, Emmanuel J., Lehner, Paul J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761574/
https://ncbi.nlm.nih.gov/pubmed/23929775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303380110
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