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Ubiquitination is essential for human cytomegalovirus US11-mediated dislocation of MHC class I molecules from the endoplasmic reticulum to the cytosol.

Human cytomegalovirus encodes two glycoproteins, US2 and US11, which cause rapid degradation of MHC class I molecules, thus preventing recognition of virus-infected cells by the immune system. This degradation process involves retrograde transport or 'dislocation' of MHC class I molecules...

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Bibliografiske detaljer
Main Authors: Kikkert, M, Hassink, G, Barel, M, Hirsch, C, van der Wal, F J, Wiertz, E
Format: Artigo
Sprog:Inglês
Udgivet: 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222069/
https://ncbi.nlm.nih.gov/pubmed/11513735
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