Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages

Myeloid cells play a critical role in perpetuating inflammation during various chronic diseases. Recently the death of macrophages through programmed necrosis (necroptosis) has emerged as an important mechanism in inflammation and pathology. We evaluated the mechanisms that lead to the induction of...

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Bibliografiske detaljer
Main Authors: McComb, Scott, Cessford, Erin, Alturki, Norah A., Joseph, Julie, Shutinoski, Bojan, Startek, Justyna B., Gamero, Ana M., Mossman, Karen L., Sad, Subash
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128105/
https://ncbi.nlm.nih.gov/pubmed/25049377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407068111
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