SERMs attenuate estrogen-induced malignant transformation of human mammary epithelial cells by upregulating detoxification of oxidative metabolites

The risk of developing hormone-dependent cancers with long-term exposure to estrogens is attributed both to proliferative, hormonal actions at the estrogen receptor (ER), and chemical carcinogenesis elicited by genotoxic, oxidative estrogen metabolites. Non-tumorigenic MCF-10A human breast epithelia...

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Detalhes bibliográficos
Main Authors: Madhubhani, L.P., Hemachandra, P., Patel, Hitisha, Esala, R., Chandrasena, P., Choi, Jaewoo, Piyankarage, Sujeewa C., Wang, Shuai, Wang, Yijin, Thayer, Emily, Scism, Rob, Michalsen, Bradley T., Xiong, Rui, Siklos, Marton, Bolton, Judy L., Thatcher, Gregory R.J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128015/
https://ncbi.nlm.nih.gov/pubmed/24598415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-13-0296
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