Long-Term Channel Block Is Required to Inhibit Cellular Transformation by Human Ether-à-Go-Go–Related Gene (hERG1) Potassium Channels

Both human ether-à-go-go–related gene (hERG1) and the closely related human ether-à-go-go (hEAG1) channel are aberrantly expressed in a large proportion of human cancers. In the present study, we demonstrate that transfection of hERG1 into mouse fibroblasts is sufficient to induce many features char...

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Hauptverfasser: Pier, David M., Shehatou, George S. G., Giblett, Susan, Pullar, Christine E., Trezise, Derek J., Pritchard, Catrin A., Challiss, R. A. John, Mitcheson, John S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4127929/
https://ncbi.nlm.nih.gov/pubmed/24830940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.091439
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