Regulation of Human CYP2C9 Expression by Electrophilic Stress Involves Activator Protein 1 Activation and DNA Looping

Cytochrome P450 (CYP)2C9 and CYP2C19 are important human enzymes that metabolize therapeutic drugs, environmental chemicals, and physiologically important endogenous compounds. Initial studies using primary human hepatocytes showed induction of both the CYP2C9 and CYP2C19 genes by tert-butylhydroqui...

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Bibliographic Details
Main Authors: Makia, Ngome L., Surapureddi, Sailesh, Monostory, Katalin, Prough, Russell A., Goldstein, Joyce A.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4127925/
https://ncbi.nlm.nih.gov/pubmed/24830941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.092585
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