Regio-selective Chemical-Enzymatic Synthesis of Pyrimidine Nucleotides Facilitates RNA Structure and Dynamics Studies

Isotope labeling revolutionized NMR studies of small nucleic acids, but to extend this technology to larger RNAs requires site-specific labeling tools to expedite NMR structural and dynamics studies. Using enzymes from the pentose phosphate pathway, we couple chemically synthesized uracil nucleobase...

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Detalhes bibliográficos
Main Authors: Alvarado, Luigi J., LeBlanc, Regan M., Longhini, Andrew P., Keane, Sarah C., Jain, Niyati, Yildiz, Zehra F., Tolbert, Blanton S., D'Souza, Victoria M., Summers, Michael F., Kreutz, Christoph, Dayie, T. Kwaku
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4127085/
https://ncbi.nlm.nih.gov/pubmed/24954297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201402130
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