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Proofreading-defective DNA polymerase II increases adaptive mutation in Escherichia coli.

The role of Escherichia coli DNA polymerase (Pol) II in producing or avoiding mutations was investigated by replacing the chromosomal Pol II gene (polB+) by a gene encoding an exonuclease-deficient mutant Pol II (polBex1). The polBex1 allele increased adaptive mutations on an episome in nondividing...

Täydet tiedot

Tallennettuna:
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Foster, P L, Gudmundsson, G, Trimarchi, J M, Cai, H, Goodman, M F
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 1995
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41264/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7644519/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.17.7951
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