Persistent prion infection disturbs the function of Oct-1, resulting in the down-regulation of murine interferon regulatory factor-3

As a prompt response against invasion of various viruses, interferon regulatory factor-3 (IRF-3) is initially phosphorylated to become activated and upregulates mainly Type I Interferons (IFN-I) in most cell types. We previously reported that IRF-3-dependent host innate immune responses partially in...

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Main Authors: Homma, Takujiro, Ishibashi, Daisuke, Nakagaki, Takehiro, Fuse, Takayuki, Sano, Kazunori, Satoh, Katsuya, Atarashi, Ryuichiro, Nishida, Noriyuki
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126003/
https://ncbi.nlm.nih.gov/pubmed/25103253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06006
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