Phosphoproteome Dynamics in Onset and Maintenance of Oncogene-induced Senescence

Expression of the BRAF(V600E) oncoprotein is known to cause benign lesions, such as melanocytic nevi (moles). Despite the oncogenic function of mutant BRAF, these lesions are arrested by a cell-autonomous mechanism called oncogene-induced senescence. Infrequently, nevi can progress to malignant mela...

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Main Authors: de Graaf, Erik L., Kaplon, Joanna, Zhou, Houjiang, Heck, Albert J. R., Peeper, Daniel S., Altelaar, A. F. Maarten
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2014
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125739/
https://ncbi.nlm.nih.gov/pubmed/24961811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M113.035436
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