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High CTLA-4 Expression on Th17 Cells Results in Increased Sensitivity to CTLA-4 Coinhibition and Resistance to Belatacept

The CD28/CTLA-4 blocker belatacept selectively inhibits alloreactive T cell responses but is associated with a high incidence of acute rejection following renal transplantation, which led us to investigate the etiology of belatacept resistant graft rejection. T cells can differentiate into functiona...

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Hlavní autoři: Krummey, Scott M., Cheeseman, Jennifer A., Conger, Jason A., Jang, Peter S., Mehta, Aneesh K., Kirk, Allan D., Larsen, Christian P., Ford, Mandy L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4124942/
https://ncbi.nlm.nih.gov/pubmed/24730049
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