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Braking Bad: Novel Mechanisms of CTLA-4 Inhibition of T Cell Responses

The coinhibitory receptor CTLA-4 is a master regulator of T cell responses and its function is critical in models of transplant tolerance. The CD28/CTLA-4 pathway is also an important therapeutic target, as the costimulation blocker belatacept was recently approved for use following renal transplant...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Transplant
Prif Awduron: Krummey, Scott M., Ford, Mandy L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364523/
https://ncbi.nlm.nih.gov/pubmed/25387592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.12938
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