White matter hyperintensities and cerebral amyloidosis: Necessary and sufficient for clinical expression of Alzheimer’s disease?

CONTEXT: Current hypothetical models emphasize the importance of beta amyloid in Alzheimer’s disease (AD) pathogenesis, although amyloid alone is not sufficient to account for the dementia syndrome. The impact of small vessel cerebrovascular disease, visualized as white matter hyperintensities (WMH)...

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Main Authors: Provenzano, Frank A., Muraskin, Jordan, Tosto, Giuseppe, Narkhede, Atul, Wasserman, Ben T., Griffith, Erica Y., Guzman, Vanessa A., Meier, Irene B., Zimmerman, Molly E., Brickman, Adam M.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4124641/
https://ncbi.nlm.nih.gov/pubmed/23420027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2013.1321
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