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Exploiting conformational dynamics in drug discovery: design of C-terminal inhibitors of Hsp90 with improved activities
[Image: see text] The interaction that occurs between molecules is a dynamic process that impacts both structural and conformational properties of the ligand and the ligand binding site. Herein, we investigate the dynamic cross-talk between a protein and the ligand as a source for new opportunities...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4123794/ https://ncbi.nlm.nih.gov/pubmed/24397468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci4005767 |
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