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Chloride sensing by WNK1 kinase involves inhibition of autophosphorylation

WNK1 [with no lysine (K)] is a serine-threonine kinase associated with a form of familial hypertension. WNK1 is at the top of a kinase cascade leading to phosphorylation of several cotransporters, in particular those transporting sodium, potassium, and chloride (NKCC), sodium and chloride (NCC), and...

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Bibliografske podrobnosti
Main Authors: Piala, Alexander T., Moon, Thomas M., Akella, Radha, He, Haixia, Cobb, Melanie H., Goldsmith, Elizabeth J.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123527/
https://ncbi.nlm.nih.gov/pubmed/24803536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005050
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