A phosphorylated intermediate in the activation of WNK kinases

WNK kinases auto-activate by autophosphorylation. Crystallography of the kinase domain of WNK1 phosphophorylated on the primary activating site (pWNK1) and in the presence of AMP-PNP reveals a well-ordered but inactive configuration. This new pWNK1 structure features specific and unique interactions...

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Publicado no:Biochemistry
Main Authors: Akella, Radha, Drozdz, Mateusz A., Humphreys, John M., Jiou, Jenny, Durbacz, Mateusz Z., Mohammed, Zuhair J., He, Haixia, Liwocha, Joanna, Sekulski, Kamil, Goldsmith, Elizabeth J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7914002/
https://ncbi.nlm.nih.gov/pubmed/32314908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00146
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