The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization

The CXC chemokine ligand (CXCL12, or stromal cell-derived factor-1 as previously known) plays a critical role for homing and retention of chronic lymphocytic leukemia (CLL) cells in tissues such as the bone marrow (BM). In tissues, stromal cells constitutively secrete and present CXCL12 via cell-sur...

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Detalhes bibliográficos
Main Authors: Hoellenriegel, Julia, Zboralski, Dirk, Maasch, Christian, Rosin, Nathalie Y., Wierda, William G., Keating, Michael J., Kruschinski, Anna, Burger, Jan A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123413/
https://ncbi.nlm.nih.gov/pubmed/24277076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-03-493924
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