Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, affecting 1–3% of the population over 65. Mutations in the ubiquitin E3 ligase parkin are the most common cause of autosomal recessive PD. The parkin protein possesses potent cell-protective properties and has bee...

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Autores principales: Charan, R A, Johnson, B N, Zaganelli, S, Nardozzi, J D, LaVoie, M J
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2014
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123072/
https://ncbi.nlm.nih.gov/pubmed/24991765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.278
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