Reduced drug incorporation into DNA and antiapoptosis as the crucial mechanisms of resistance in a novel nelarabine-resistant cell line

BACKGROUND: Nine-beta-D-arabinofuranosylguanine (ara-G), an active metabolite of nelarabine, enters leukemic cells through human Equilibrative Nucleoside Transporter 1, and is then phosphorylated to an intracellular active metabolite ara-G triphosphate (ara-GTP) by both cytosolic deoxycytidine kinas...

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Hlavní autoři: Yamauchi, Takahiro, Uzui, Kanako, Nishi, Rie, Shigemi, Hiroko, Ueda, Takanori
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122765/
https://ncbi.nlm.nih.gov/pubmed/25070259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-547
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