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All-atomic Molecular Dynamic Studies of Human CDK8: Insight into the A-loop, Point Mutations and Binding with Its Partner CycC

The Mediator, a conserved multisubunit protein complex in eukaryotic organisms, regulates gene expression by bridging sequence-specific DNA-binding transcription factors to the general RNA polymerase II machinery. In yeast, Mediator complex is organized in three core modules (head, middle and tail)...

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Bibliografiska uppgifter
Huvudupphovsmän: Xu, Wu, Amire-Brahimi, Benjamin, Xie, Xiao-Jun, Huang, Liying, Ji, Jun-Yuan
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122639/
https://ncbi.nlm.nih.gov/pubmed/24754906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.compbiolchem.2014.03.003
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