Ultra-performance liquid chromatography tandem mass spectrometry method for the determination of AZ66, a sigma receptor ligand, in rat plasma and its application to in vivo pharmacokinetics

Methamphetamine abuse continues as a major problem in the USA owing to its powerful psychological addictive properties. AZ66, 3-[4-(4-cyclohexylpiperazine-1-yl)pentyl]-6-fluorobenzo[d]thiazole-2(3H)-one, an optimized sigma receptor ligand, is a promising therapeutic agent against methamphetamine. To...

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Hauptverfasser: Jamalapuram, Seshulatha, Vuppala, Pradeep Kumar, Abdelazeem, Ahmed H., McCurdy, Christopher R., Avery, Bonnie A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122523/
https://ncbi.nlm.nih.gov/pubmed/23558564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bmc.2901
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