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AAV Mediated Expression of Human PRELP inhibits Complement Activation, Choroidal Neovascularization and Deposition of Membrane Attack Complex in Mice

Age related macular degeneration (AMD) is the leading cause of blindness among the elderly. Approximately 50% of AMD patients have a polymorphism in the negative regulator of complement known as Factor H. Individuals homozygous for a Y402H polymorphism in Factor H have elevated levels of membrane at...

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書誌詳細
主要な著者: Birke, Marco T., Lipo, Erion, Adhi, Mehreen, Birke, Kerstin, Kumar-Singh, Rajendra
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122322/
https://ncbi.nlm.nih.gov/pubmed/24670995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2014.24
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