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AAV Mediated Expression of Human PRELP inhibits Complement Activation, Choroidal Neovascularization and Deposition of Membrane Attack Complex in Mice
Age related macular degeneration (AMD) is the leading cause of blindness among the elderly. Approximately 50% of AMD patients have a polymorphism in the negative regulator of complement known as Factor H. Individuals homozygous for a Y402H polymorphism in Factor H have elevated levels of membrane at...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4122322/ https://ncbi.nlm.nih.gov/pubmed/24670995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2014.24 |
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