Aurintricarboxylic Acid Inhibits Complement Activation, Membrane Attack Complex, and Choroidal Neovascularization in a Model of Macular Degeneration

PURPOSE. Immunocytochemical and genetic data implicate a significant role for the activation of complement in the pathology of AMD. Individuals homozygous for a Y402H polymorphism in Factor H have elevated levels of membrane attack complex (MAC) in their choroidal blood vessels and RPE relative to i...

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Main Authors: Lipo, Erion, Cashman, Siobhan M., Kumar-Singh, Rajendra
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3813320/
https://ncbi.nlm.nih.gov/pubmed/24106121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-12923
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