Age-related dysfunction in mechano-transduction impairs differentiation of human mammary epithelial progenitors

Dysfunctional progenitor and luminal cells with acquired basal cell properties accumulate during human mammary epithelia aging for reasons not understood. Multipotent progenitors from women aged <30 years were exposed to a physiologically relevant range of matrix elastic modulus, and increased ri...

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Huvudupphovsmän: Pelissier, Fanny A., Garbe, James C., Ananthanarayanan, Badriprasad, Miyano, Masaru, Lin, ChunHan, Jokela, Tiina, Kumar, Sanjay, Stampfer, Martha R., Lorens, James B., LaBarge, Mark A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122253/
https://ncbi.nlm.nih.gov/pubmed/24910432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.05.021
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