Structure activity relationship of phenolic acid inhibitors of α-synuclein fibril formation and toxicity

The aggregation of α-synuclein (α-syn) is considered the key pathogenic event in many neurological disorders such as Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy, giving rise to a whole category of neurodegenerative diseases known as synucleinopathies. Althoug...

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Hlavní autoři: Ardah, Mustafa T., Paleologou, Katerina E., Lv, Guohua, Abul Khair, Salema B., Kazim, Abdulla S., Minhas, Saeed T., Al-Tel, Taleb H., Al-Hayani, Abdulmonem A., Haque, Mohammed E., Eliezer, David, El-Agnaf, Omar M. A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2014
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122169/
https://ncbi.nlm.nih.gov/pubmed/25140150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2014.00197
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