Silencing of Glucocerebrosidase Gene in Drosophila Enhances the Aggregation of Parkinson's Disease Associated α-Synuclein Mutant A53T and Affects Locomotor Activity

Background: Mutations in glucocerebrosidase (GBA), a lysosomal enzyme are the most common genetic risk factor for developing Parkinson's disease (PD). We studied how reduced GCase activity affects α-synuclein (α-syn) and its mutants (A30P and A53T) aggregation, neurodegeneration, sleep and loco...

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Bibliografiske detaljer
Udgivet i:Front Neurosci
Main Authors: Abul Khair, Salema B., Dhanushkodi, Nisha R., Ardah, Mustafa T., Chen, Wenfeng, Yang, Yufeng, Haque, M. Emdadul
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5820349/
https://ncbi.nlm.nih.gov/pubmed/29503608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00081
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