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Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter

ATP binding cassette (ABC) transporters mediate vital transport processes in every living cell. ATP hydrolysis, which fuels transport, displays positive cooperativity in numerous ABC transporters. In particular, heterodimeric ABC exporters exhibit pronounced allosteric coupling between a catalytical...

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Bibliografiske detaljer
Main Authors: Hohl, Michael, Hürlimann, Lea M., Böhm, Simon, Schöppe, Jendrik, Grütter, Markus G., Bordignon, Enrica, Seeger, Markus A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121816/
https://ncbi.nlm.nih.gov/pubmed/25030449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400485111
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