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Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter

ATP binding cassette (ABC) transporters mediate vital transport processes in every living cell. ATP hydrolysis, which fuels transport, displays positive cooperativity in numerous ABC transporters. In particular, heterodimeric ABC exporters exhibit pronounced allosteric coupling between a catalytical...

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Détails bibliographiques
Auteurs principaux: Hohl, Michael, Hürlimann, Lea M., Böhm, Simon, Schöppe, Jendrik, Grütter, Markus G., Bordignon, Enrica, Seeger, Markus A.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121816/
https://ncbi.nlm.nih.gov/pubmed/25030449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400485111
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