Structural effects of PrP polymorphisms on intra- and interspecies prion transmission

Understanding the molecular parameters governing prion propagation is crucial for controlling these lethal, proteinaceous, and infectious neurodegenerative diseases. To explore the effects of prion protein (PrP) sequence and structural variations on intra- and interspecies transmission, we integrate...

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Bibliografiske detaljer
Main Authors: Angers, Rachel, Christiansen, Jeffrey, Nalls, Amy V., Kang, Hae-Eun, Hunter, Nora, Hoover, Edward, Mathiason, Candace K., Sheetz, Michael, Telling, Glenn C.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121815/
https://ncbi.nlm.nih.gov/pubmed/25034251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1404739111
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