Structural effects of PrP polymorphisms on intra- and interspecies prion transmission

Understanding the molecular parameters governing prion propagation is crucial for controlling these lethal, proteinaceous, and infectious neurodegenerative diseases. To explore the effects of prion protein (PrP) sequence and structural variations on intra- and interspecies transmission, we integrate...

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Bibliografiska uppgifter
Huvudupphovsmän: Angers, Rachel, Christiansen, Jeffrey, Nalls, Amy V., Kang, Hae-Eun, Hunter, Nora, Hoover, Edward, Mathiason, Candace K., Sheetz, Michael, Telling, Glenn C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2014
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121815/
https://ncbi.nlm.nih.gov/pubmed/25034251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1404739111
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