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Structural effects of PrP polymorphisms on intra- and interspecies prion transmission

Understanding the molecular parameters governing prion propagation is crucial for controlling these lethal, proteinaceous, and infectious neurodegenerative diseases. To explore the effects of prion protein (PrP) sequence and structural variations on intra- and interspecies transmission, we integrate...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Angers, Rachel, Christiansen, Jeffrey, Nalls, Amy V., Kang, Hae-Eun, Hunter, Nora, Hoover, Edward, Mathiason, Candace K., Sheetz, Michael, Telling, Glenn C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121815/
https://ncbi.nlm.nih.gov/pubmed/25034251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1404739111
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