APOL1 risk variants enhance podocyte necrosis through compromising lysosomal membrane permeability

Development of higher rates of nondiabetic glomerulosclerosis (GS) in African Americans has been attributed to two coding sequence variants (G1 and G2) in the APOL1 gene. To date, the cellular function and the role of APOL1 variants (Vs) in GS are still unknown. In this study, we examined the effect...

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Hauptverfasser: Lan, Xiqian, Jhaveri, Aakash, Cheng, Kang, Wen, Hongxiu, Saleem, Moin A., Mathieson, Peter W., Mikulak, Joanna, Aviram, Sharon, Malhotra, Ashwani, Skorecki, Karl, Singhal, Pravin C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121568/
https://ncbi.nlm.nih.gov/pubmed/24899058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00647.2013
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