Impact of APOL1 polymorphism and IL-1β priming in the entry and persistence of HIV-1 in human podocytes

BACKGROUND: Patients of African ancestry with untreated HIV-1 infection and carrying the G1 or G2 kidney disease risk variants (Vs) at the APOL1 gene have a tenfold higher risk of developing HIV-associated nephropathy (HIVAN) compared to those with the non-risk wild type (WT) G0 variant. However, th...

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Publicat a:Retrovirology
Autors principals: Mikulak, Joanna, Oriolo, Ferdinando, Portale, Federica, Tentorio, Paolo, Lan, Xiqian, Saleem, Moin A., Skorecki, Karl, Singhal, Pravin C., Mavilio, Domenico
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5011791/
https://ncbi.nlm.nih.gov/pubmed/27599995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-016-0296-3
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