Utilizing Population Controls in Rare-Variant Case-Parent Association Tests

There is great interest in detecting associations between human traits and rare genetic variation. To address the low power implicit in single-locus tests of rare genetic variants, many rare-variant association approaches attempt to accumulate information across a gene, often by taking linear combin...

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Bibliographic Details
Main Authors: Jiang, Yu, Satten, Glen A., Han, Yujun, Epstein, Michael P., Heinzen, Erin L., Goldstein, David B., Allen, Andrew S.
Format: Artigo
Language:Inglês
Published: Elsevier 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121482/
https://ncbi.nlm.nih.gov/pubmed/24836453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2014.04.014
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