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A weighted accumulation test for associating rare genetic variation with quantitative phenotypes
Currently there is a great deal of interest in developing methods for testing the role that rare variation plays in disease development. Here we propose a weighted association test that accumulates genetic variation across a signaling pathway. We evaluate our approach by analyzing simulated phenotyp...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3287898/ https://ncbi.nlm.nih.gov/pubmed/22373271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1753-6561-5-S9-S6 |
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