Inhibition of Cdk2 kinase activity selectively targets the CD44(+)/CD24(−/Low) stem-like subpopulation and restores chemosensitivity of SUM149PT triple-negative breast cancer cells

Inflammatory breast cancer (IBC) is an angioinvasive and most aggressive type of advanced breast cancer characterized by rapid proliferation, chemoresistance, early metastatic development and poor prognosis. IBC tumors display a triple-negative breast cancer (TNBC) phenotype characterized by centros...

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Hauptverfasser: OPYRCHAL, MATEUSZ, SALISBURY, JEFFREY L., IANKOV, IANKO, GOETZ, MATHEW P., McCUBREY, JAMES, GAMBINO, MARIO W., MALATINO, LORENZO, PUCCIA, GIUSEPPE, INGLE, JAMES N., GALANIS, EVANTHIA, D’ASSORO, ANTONINO B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: D.A. Spandidos 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121417/
https://ncbi.nlm.nih.gov/pubmed/24970653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2014.2523
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