Molecular targeting of the Aurora-A/SMAD5 oncogenic axis restores chemosensitivity in human breast cancer cells

Although the majority of breast cancers initially respond to the cytotoxic effects of chemotherapeutic agents, most breast cancer patients experience tumor relapse and ultimately die because of drug resistance. Breast cancer cells undergoing epithelial to mesenchymal transition (EMT) acquire a CD44(...

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Vydáno v:Oncotarget
Hlavní autoři: Opyrchal, Mateusz, Gil, Malgorzata, Salisbury, Jeffrey L., Goetz, Mathew P., Suman, Vera, Degnim, Amy, McCubrey, James, Haddad, Tufia, Iankov, Ianko, Kurokawa, Chenye B., Shumacher, Nicole, Ingle, James N., Galanis, Evanthia, D’Assoro, Antonino B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5710966/
https://ncbi.nlm.nih.gov/pubmed/29207686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20610
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