Molecular targeting of the Aurora-A/SMAD5 oncogenic axis restores chemosensitivity in human breast cancer cells

Although the majority of breast cancers initially respond to the cytotoxic effects of chemotherapeutic agents, most breast cancer patients experience tumor relapse and ultimately die because of drug resistance. Breast cancer cells undergoing epithelial to mesenchymal transition (EMT) acquire a CD44(...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Opyrchal, Mateusz, Gil, Malgorzata, Salisbury, Jeffrey L., Goetz, Mathew P., Suman, Vera, Degnim, Amy, McCubrey, James, Haddad, Tufia, Iankov, Ianko, Kurokawa, Chenye B., Shumacher, Nicole, Ingle, James N., Galanis, Evanthia, D’Assoro, Antonino B.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5710966/
https://ncbi.nlm.nih.gov/pubmed/29207686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20610
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