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Inhibition of Rho associated coiled-coil forming kinase increases efficacy of measles virus infection in vitro and in vivo

RhoA and its downstream effector, Rho associated coiled-coil forming kinase (ROCK) are known regulators of formation of actin cytoskeleton in cells. Actin cytoskeleton is involved in paramyxovirus infection. We examined the effect of ROCK inhibition on MV cytopathic effect and replication. Treatment...

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Main Authors: Opyrchal, Mateusz, Allen, Cory, Msaouel, Pavlos, Iankov, Ianko, Galanis, Evanthia
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903406/
https://ncbi.nlm.nih.gov/pubmed/24157925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2013.58
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