Enhanced anti-colorectal cancer effects of carfilzomib combined with CPT-11 via downregulation of nuclear factor-κB in vitro and in vivo

Upregulation of nuclear factor-κB (NF-κB) in colorectal carcinoma (CRC) accelerates tumor growth, whereas, irinotecan (CPT-11)-induced NF-κB activation reduces chemosensitivity and weakens the anti-colorectal cancer function itself, while proteasome inhibitors can inhibit NF-κB and improve the effec...

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Main Authors: TANG, WEIWEI, SU, GUANGJIAN, LI, JIEYU, LIAO, JINRONG, CHEN, SHUPING, HUANG, CHUANZHONG, LIU, FANG, CHEN, QIANG, YE, YUNBIN
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121410/
https://ncbi.nlm.nih.gov/pubmed/24968890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2014.2513
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