Unique Pattern of Component Gene Disruption in the NRF2 Inhibitor KEAP1/CUL3/RBX1 E3-Ubiquitin Ligase Complex in Serous Ovarian Cancer

The NFE2-related factor 2 (NRF2) pathway is critical to initiate responses to oxidative stress; however, constitutive activation occurs in different cancer types, including serous ovarian carcinomas (OVCA). The KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex is a regulator of NRF2 levels. Hence, we inve...

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Главные авторы: Martinez, Victor D., Vucic, Emily A., Thu, Kelsie L., Pikor, Larissa A., Hubaux, Roland, Lam, Wan L.
Формат: Artigo
Язык:Inglês
Опубликовано: Hindawi Publishing Corporation 2014
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121105/
https://ncbi.nlm.nih.gov/pubmed/25114896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/159459
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