Genetic Disruption of KEAP1/CUL3 E3 Ubiquitin Ligase Complex Components is a Key Mechanism of NF-kappaB Pathway Activation in Lung Cancer

INTRODUCTION: IKBKB (IKK-β/IKK-2), which activates NF-κB, is a substrate of the KEAP1-CUL3-RBX1 E3-ubiquitin ligase complex, implicating this complex in regulation of NF-κB signaling. We investigated complex component gene disruption as a novel genetic mechanism of NF-κB activation in non-small cell...

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Main Authors: Thu, Kelsie L., Pikor, Larissa A., Chari, Raj, Wilson, Ian M., MacAulay, Calum E., English, John C., Tsao, Ming-Sound, Gazdar, Adi F., Lam, Stephen, Lam, Wan L., Lockwood, William W.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164321/
https://ncbi.nlm.nih.gov/pubmed/21795997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0b013e3182289479
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