Lung Adenocarcinoma of Never Smokers and Smokers Harbor Differential Regions of Genetic Alteration and Exhibit Different Levels of Genomic Instability

Recent evidence suggests that the observed clinical distinctions between lung tumors in smokers and never smokers (NS) extend beyond specific gene mutations, such as EGFR, EML4-ALK, and KRAS, some of which have been translated into targeted therapies. However, the molecular alterations identified th...

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Главные авторы: Thu, Kelsie L., Vucic, Emily A., Chari, Raj, Zhang, Wei, Lockwood, William W., English, John C., Fu, Rong, Wang, Pei, Feng, Ziding, MacAulay, Calum E., Gazdar, Adi F., Lam, Stephen, Lam, Wan L.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296775/
https://ncbi.nlm.nih.gov/pubmed/22412972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033003
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