Lung Adenocarcinoma of Never Smokers and Smokers Harbor Differential Regions of Genetic Alteration and Exhibit Different Levels of Genomic Instability

Recent evidence suggests that the observed clinical distinctions between lung tumors in smokers and never smokers (NS) extend beyond specific gene mutations, such as EGFR, EML4-ALK, and KRAS, some of which have been translated into targeted therapies. However, the molecular alterations identified th...

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Hauptverfasser: Thu, Kelsie L., Vucic, Emily A., Chari, Raj, Zhang, Wei, Lockwood, William W., English, John C., Fu, Rong, Wang, Pei, Feng, Ziding, MacAulay, Calum E., Gazdar, Adi F., Lam, Stephen, Lam, Wan L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296775/
https://ncbi.nlm.nih.gov/pubmed/22412972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033003
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