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Mapping the Protein Interaction Landscape for Fully Functionalized Small-Molecule Probes in Human Cells

[Image: see text] Phenotypic screening provides a means to discover small molecules that perturb cell biological processes. Discerning the proteins and biochemical pathways targeted by screening hits, however, remains technically challenging. We recently described the use of small molecules bearing...

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Autors principals: Kambe, Tohru, Correia, Bruno E., Niphakis, Micah J., Cravatt, Benjamin F.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4120992/
https://ncbi.nlm.nih.gov/pubmed/25045785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja505517t
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