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Mapping the Protein Interaction Landscape for Fully Functionalized Small-Molecule Probes in Human Cells

[Image: see text] Phenotypic screening provides a means to discover small molecules that perturb cell biological processes. Discerning the proteins and biochemical pathways targeted by screening hits, however, remains technically challenging. We recently described the use of small molecules bearing...

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Detalles Bibliográficos
Main Authors: Kambe, Tohru, Correia, Bruno E., Niphakis, Micah J., Cravatt, Benjamin F.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2014
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4120992/
https://ncbi.nlm.nih.gov/pubmed/25045785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja505517t
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