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Fully functionalized small-molecule probes for integrated phenotypic screening and target identification
Phenotypic screening offers a powerful approach to identify small-molecules that perturb complex biological processes in cells and organisms. The tendency of small molecules, however, to interact with multiple protein targets, often with moderate to weak affinities, along with the lack of straightfo...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3426452/ https://ncbi.nlm.nih.gov/pubmed/22667687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja304213w |
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